Programme
View the IrSPEN 2025 schedule

Professor Carel Le Roux Chair of IrSPEN
Professor Carel le Roux graduated from medical school in Pretoria South Africa, completed his specialist training in metabolic medicine at St Bartholomew’s Hospitals and the Hammersmith Hospitals, his PhD at Imperial College London and was later promoted to Reader. He moved to University College Dublin for the Chair in Pathology and he is now the Co-Director of the Metabolic Medicine Group. He previously received a President of Ireland Young Researcher Award, Clinician Scientist Award from the National Institute Health Research in the UK, a Welcome Trust Clinical Research Fellowship for his work on how the gut talks to the brain.
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Dr Melissa Conroy
Dr Conroy’s patient-oriented research focuses on identifying and developing new immunotherapeutic approaches for poor prognosis cancers, inflammation and neurological disorders. She has been awarded multiple national and international research grants and published over 40 publications in this space in leading journals such as Journal of Immunology, Nature, Scientific Reports, Cancer Letters and Gut.
One of Dr Conroy’s key research goals is to further elucidate how the condition of obesity influences immunotherapy efficacy in patients with cancer and to develop innovative therapeutic strategies to overcome the negative effects of excess adiposity. Dr Conroy’s group are currently developing a tumour-homing Natural Killer cell therapy with the overarching aim of improving treatment response and survival rates for patients with obesity-associated cancer.
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Treating the patient with obesity: novel solutions and implications from an immunological perspective
Oesophageal adenocarcinoma (OAC) is an obesity-associated cancer, underpinned by severe immune dysregulation and inflammation. The dismal 5-year survival rate for oesophageal adenocarcinoma of less than 25%, is largely due to poor treatment response rates of less than 30%. Furthermore, current immunotherapies available for OAC have an efficacy of less than 25% meaning a large proportion of patients do not derive any clinical benefit from them. As such, this growing group of cancer patients urgently require new options, and we propose that novel natural killer (NK) cell-based chemokine-targeted immunotherapies could help address this unmet need.
Cellular immunotherapies encounter two key challenges to their success in OAC, namely recruitment to extratumoural tissues such as the omentum at the expense of the tumour and an immunosuppressive tumour microenvironment (TME) which can hamper NK cell function.
This study examined approaches to overcome the detrimental impact of obesity on NK cell-based immunotherapies. We have demonstrated that NK cells migrate preferentially to the chemotactic signals of OAC patient-derived omentum over tumour in an ex vivo model of immune cell migration. We have identified CX3CR1 modulation and/or tumour chemokine profile remodelling as approaches to skew NK cell migration towards tumour. We also report targetable immunosuppressive facets of tumours derived from OAC patients with obesity, which dampen NK cell function, in particular cytotoxic capabilities.
These data provide insights into approaches to therapeutically overcome key challenges presented by obesity and will inform superior design of NK cell-based immunotherapies for OAC.
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Identifying key players in the progression of oesophageal cancer cachexia
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Dr Mick Crotty
Dr Michael Crotty is a General Practitioner who specialises in Obesity Medicine. Dr Crotty is the HSE/Irish College of GP Clinical Lead for Obesity and is a member of the Clinical Advisory Group of the Irish National Clinical Programme for Obesity. He was awarded a SCOPE National Fellowship by the World Obesity Federation. Michael is the co-founder and clinical lead of the “My Best Weight” Clinic in Dublin, Ireland.
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How can GPs work with community dieticians to improve health outcomes of obesity medications?
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Dr. Dolores Dolores Sanchez-Rodriguez
Dr. Dolores Dolores Sanchez-Rodriguez, MD, PhD, is a geriatric medicine specialist with expertise in malnutrition, sarcopenia, and frailty in older adults. She obtained her doctoral degree in sarcopenia in older people from the Universitat Autònoma de Barcelona in 2016. She is currently serving as Head of Clinics at Brugmann University Hospital – Universite Libre de Bruxelles, in Brussels, Belgium since 2020.
With 79 scientific publications and an H-index of 23 (details available in: https://www.ncbi.nlm.nih.gov/myncbi/dolores.sanchez%20rodriguez.1/bibliography/public/), she also serves as an Editorial Board member for Maturitas and Associate Editor for Clinical Nutrition ESPEN. She is an active member of the ESPEN SIG on Geriatrics and the EuGMS SIG on malnutrition, SIG on sarcopenia, and SIG on Systematic Reviews and Meta-analysis.
Dr. Sanchez-Rodriguez co-leads the project Core Outcome Set (COS) for Sarcopenia Intervention Studies, an initiatie under the newly stablished Global Leadership Initiative on Sarcopenia (GLIS). She has recently joined the SAGeR Steering Committee for Standardization in Aging & Geroscience Research by the Canadian Frailty Network. In her free time, she enjoys running, traveling, and outdoor activities.
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Session 4. Interventions that work in interrupting the frailty cycle at critical junctures in disease and aging.
The objective of the 20-minute talk is to provide an updated overview of frailty. The talk content is structured according to recommendations for conducting an annual literature update on top articles relevant to clinical practice in geriatrics.
Three key points will be explored, as follows:
Given the extensive body of evidence on interventions which have shown effectiveness in frailty and the time constraint, the talk has been developed to spark interest and foster curiosity in this fascinating topic, providing a starting point for the audience to continue learning independently and deepen their understanding and knowledge after the conference.
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Changing the patient journey towards frailty requires intervention at critical junctures
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Dr Karen Boland, Consultant Gastroenterologist, IrSPEN Director
Karen graduated with an honours degree from the School of Medicine at RCSI in 2007 and is currently appointed as a Consultant Gastroenterologist at Beaumont Hospital with an interest in inflammatory bowel disease and clinical nutrition. She completed an advanced fellowship in microbiome analysis, diet analysis and inflammatory bowel disease at Mount Sinai Hospital Toronto. Her current research interests include therapeutic drug monitoring in IBD, microbiome analysis and the impact of diet and exercise programmes on outcomes in moderate to severe IBD. Karen is a member of the board of IRSPEN and chair of their Scientific Committee.
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Aideen McGuinness, Senior Dietitian, M.I.N.D.I. Aideen McGuinness, Senior Dietitian, M.I.N.D.I.
Aideen qualified from Trinity College Dublin/Dublin Institute of Technology as a Dietitian and Nutritionist over 30 years ago, and worked for many years in various Irish hospitals, including as a Clinical Specialist Dietitian in intensive care & nutrition support. After a 15 year detour to the French Camino route, she is now working in Wexford as part of two Community Specialist Teams for Older Persons – Wexford Integrated Care for Older Persons (WexICOP) and Wexford Memory Assessment and Support Service (WexMASS). She is an active member of the INDI (Irish Nutrition & Dietetic Institute) and part of a working group of the Dietitians involved in Integrated Care for Older Persons (ICPOP) nationally.
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The key role of nutrition in frailty in the older person is recognised and the dietetic approach has evolved, though outside of our small group of ICPOP Dietitians certain aspects may not be as well known. I will discuss aspects of nutrition screening, functional assessments, outcomes, first line advice, and the importance of education and communication as well as direct client contact to continue to highlight the benefits of nutrition awareness in frailty, its potential reversibility, and avoidance.
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The Evolving Role of the Dietitian in the Management of Frailty
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Prof. Dr. Philip J Atherton; Chair of Clinical, Metabolic & Molecular Physiology
Since PhD award (2005) he has been awarded (PI/Co-I) >£20M funding from government, charities, industry and EU sources. He has published ~300 peer-reviewed articles (H-index 74), with ~27,000 citations, an i10 index of 179, and 8 invited book(s) chapters. He is Senior Editor for Translational Exercise Biomedicine, section Editor-In-Chief of Nutrients and Editor-In-Chief of Physiologia. He is a member of the UK’s Medical Research Council (MRC) Population & Systems Medicine Board (PSMB). His work combines clinical physiology with stable isotope tracers, OMICs, and basic in vivo/vitro molecular biology to discover the mechanistic basis for and means to mitigate health and musculoskeletal declines in ageing and disease(s).
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Physical therapy interventions combined with nutrition- what works and how to translate research into practice
Exercise is a potent anabolic stimulus in skeletal muscle. Exercise stimulates muscle anabolism across the lifecourse although anabolic responsiveness is dampened with advancing age due to endocrine and local (i.e., mechanotransduction) deficits. As such, practical interventions need to account for these intrinsic deficits in addition to any associated practical and/or physical limitations e.g., owing to the clinical setting or presence of limiting age-associated conditions. The most potent anabolic stimulus relating to skeletal muscle is resistance exercise training (RET). RET stimulates muscle protein synthesis, and while causing more limited hypertrophy in older age, markedly enhances physical functioning. Immobilization induces the opposite effects, causing rapid muscle declines which may be exacerbated by age. The interaction between nutrition and exercise/inactivity may profoundly impact the efficacy of interventions – the mechanistic basis of which will be introduced. Novel interventions for future implementation, such as non-voluntary contraction in the form of electrical stimulation will be discussed.
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Niamh Rice
Niamh Rice is a director and founding member of IrSPEN and an independent consultant specialising in nutrition and medical affairs. In January 2021, she was appointed Executive Director of the European Nutrition for Health Alliance (ENHA), which aims to ensure that all EU citizens at risk of nutritional problems due to ageing or disease benefit from optimal nutritional care. Qualified in Nutrition and Dietetics, Niamh has over 25 years’ experience working in senior scientific, general management and global director positions within nutrition companies in Ireland, UK and Netherlands. Within IrSPEN, Niamh has directed strategy and communications and has actively campaigned for improved standards of nutritional care, applying her knowledge of business strategy and health economics to underpin IrSPEN’s advocacy and campaigning efforts. Her work on developing a national costing for malnutrition was published in 2012, and she has also written or contributed to several clinical papers, expert reports, government submissions, reviews and business case submissions on behalf of non-governmental agencies and professional groups. As chair of IrSPEN’s programmes and communication committee, Niamh has also worked on initiatives aimed at gaining a better understanding of the needs of patients who experience nutritional problems, including patients receiving home nutrition support and patients with cancer. In the last few years, Niamh has served on national advisory committees on nutrition and hydration for both HIQA and the HSE, developing the budget impact analysis to support new clinical guidelines for nutrition screening of patients in acute care settings in Ireland, launched December 2020.
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In 2011, when we last estimated the prevalence and cost of disease-related malnutrition in Ireland, adults over 65 made up just 11.4% of the population. Since then, Ireland has experienced the fastest rate of population aging in Europe, with the number of older adults increasing by over 55% and projected to reach one million within the next decade. Given the well-established link between aging, chronic disease, and nutritional deterioration, this demographic shift has significantly increased the scale and economic burden of malnutrition on our healthcare system.
This presentation will provide new insights into the current prevalence and cost of malnutrition, drawing on data from the 2023 IrSPEN/INDI National Malnutrition Survey—potentially the largest study of its kind relative to the population, with data captured for approximately one-third of all adult inpatients. Findings will highlight the considerable financial burden of malnutrition on Ireland’s health system, reinforcing its role as a major but frequently overlooked driver of healthcare costs—much of which could be mitigated through a focus on earlier and more effective interventions aimed at preserving or regaining function.
Notably, data from the 2023 survey suggests that while mandatory malnutrition screening and earlier intervention in acute care may be delivering measurable benefits, the overall prevalence of malnutrition risk at hospital admission continues to rise in line with the upward trend in age of the patient population, with a higher incidence of cancer. Whilst the latest costing of malnutrition demonstrates that the vast majority of costs associated with malnutrition are incurred in acute care settings, it will be shown that the largest potential for saving money is through effective strategies for prevention of malnutrition in those living independently or semi independently in their own home. Putative cost savings will be presented for reducing the burden of malnutrition of those entering the hospital system, based on the estimated excess costs of a malnourished older patient per year vs a normally nourished older person.
From a health economics perspective, we must ask whether a shift in how we view and respond to malnutrition is needed. Should malnutrition be recognised as a modifiable and costly co-morbidity of disease, particularly severe in older adults, rather than an inevitable consequence of illness? Given the enormous costs associated with malnutrition, both in terms of healthcare utilisation and the long-term burden on social care, what will it cost if we fail to address the factors driving malnutrition in the community—where early intervention could prevent hospitalisations, reduce complications, and improve recovery outcomes?
By integrating health economics into nutrition policy and practice, this presentation will explore how targeted interventions could maximise savings across both health and social care while improving patient outcomes. The question remains: will we adapt, or will we continue to absorb the escalating costs of a problem that is, in many cases, preventable?
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Malnutrition Prevalence and Cost
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Dr Werd Al-Najim; Dietitian/Clinical Nutritionist Project Manager, University College Dublin
Dr Werd Al-Najim is a Clinical Nutritionist and a Research Fellow at University College Dublin/Ireland. She holds a bachelor’s degree in nutrition science from Kingston University/UK and a PhD from Imperial College London/UK where she investigated changes in eating behaviour and food preferences after obesity treatments. She also holds a health coaching certificate from the Integrative Nutrition School/New York and a Cognitive Behavior Therapy certificate from City Colleges/Dublin.
Werd has a special interest in obesity research and has contributed to high impact publications in journals including Physiological Reviews, Lancet Diabetes and Endocrinology, and The Journal of Clinical Endocrinology & Metabolism.
Werd recognises public education and treatment involvement as key elements of contemporary medical practice. In this regard, she plays a leadership role by holding educational events around the world. She has presented TV Programmes for more than 8 years and co-leads a health and science social media platform followed by more than 113k people.
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HOW CAN DIETITIANS SUPPORT PATIENTS RECEIVING PHARMACOTHERAPY FOR OBESITY?
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Dr Lisa Shanahan; Clinical Specialist Dietitian, Mater Misericordiae University Hospital
Lisa Shanahan is a Clinical Specialist Dietitian in Critical Care at the Mater University Hospital Dublin. She has been working in critical care for over 17 years. She leads the ICU Dietitians Network Ireland, a forum for sharing information and supporting dietitians working in critical care nationally and is a lead member of the Mater Critical Care Health and Social Professional Team.
She has a strong interest in data analytics, audit and research. She has lead her critical care unit’s involvement in the International Nutrition Surveys and more recently in joint research projects between Monash University, Australia and UCD’s Critical Care Trial Network in research on Post ICU Nutrition Status in COVID patients and NUTRIENT, a study of nutrition practices in and post ICU. Her work includes a keen focus on using data to improve patient care.
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Measuring Effectiveness in ICU Dietetics
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Dr Erin Stella Sullivan; Lecturer in Nutritional Sciences, King’s College London
Erin is a CORU and HCPC Registered Dietitian, Lecturer in Nutritional Sciences at King’s College London and former IRC Enterprise Partnership Scheme Postdoctoral Fellow.
Her research focus is on malnutrition, body composition and nutritional behaviours and experiences of people living with and beyond cancer.
She has expertise in advanced body composition and dietetic assessment techniques such as CT and ultrasound as well as clinical trials of bioactive peptides, oral nutritional supplements and multimodal interventions to prevent nutritional deterioration in cancer.
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Muscle, fat & frailty: insights and implications for nutrition in cancer care
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Dr Carmel O Hanlon; Clinical Specialist Dietitian, Beaumont Hospital
Carmel has worked as a clinical dietitian for over 25 years, and currently specialises in the nutritional management of ICU patients and nutrition support. She was a co-ordinator of the Irish Nutrition and Dietetic Institute’s (INDI) Nutrition Support Reference Guide for dietitians published in 2015, and is a Therapy Professions lead on the Critical Care Programme of the National Clinical Strategy and Programmes Directorate. She is a Board member of the Irish Society for Clinical Nutrition and Metabolism (IrSPEN) and Chairs IrSPEN’s Policy and Practice Committee. Carmel is an Honorary Member of the INDI. She has recently taken on a role for the HSE to co-ordinate the development of NCEC (National Clinical Effectiveness Committee) National Clinical Guidelines for the ‘Prevention and treatment of undernutrition: use of nutrition support in adults in the acute care setting.’
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Prof. Helen Heneghan; Consultant Bariatric Surgeon & UCD Professor of Surgery, St Vincent’s University Hospital
MB BCh BAO, PhD, FRCS
Prof. Heneghan is a graduate of NUI Galway, and completed basic surgical training in Galway University Hospital. She has co-authored 60 publications in peer-reviewed journals and has written 5 book chapters on the topics of bariatric and endocrine surgery.
2012 – Awarded a PhD in the molecular expression of breast cancer and obesity from NUI Galway.
2016 – Completed the RCSI Higher Surgical Training scheme in General Surgery. During her training, she spent two years in the Bariatric Metabolic Institute in Cleveland Clinic, Ohio.
Completed her training with a Bariatric Fellowship in the UK (Chester, Liverpool).
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A/Prof Emma Ridley, ANZIC-RC, Monash University and Alfred Health
Emma is an Associate Professor, National Health and Medical Research Council Emerging Leadership Fellow and heads the Nutrition Program at the Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia. With over 15 years of experience in critical care nutrition research, Emma completed her PhD in 2018. Emma focuses on long-term nutrition interventions for the critically ill and is internationally recognized for her expertise (ranked in the top 1% on Expertscape for multiple critical care and clinical nutrition topics). She has over 125 peer-reviewed publications and has secured over $16.8 million in research funding, including $5.8 million as CIA. Emma is the CI-A on the recently completed INTENT trial and was awarded a $1.49 million MRFF 2022 grant titled “A national platform for improving quality of nutrition care for critically ill adults and children”. Emma also practices as a clinical dietitian at The Alfred Hospital, Melbourne.
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Rachel Clyne; Senior dietitian in critical care in Beaumont Hospital
Rachel is a senior dietitian in critical care in Beaumont Hospital. She qualified from DIT Kevin Street/TCD in 2015. She has spent the majority of her career working in Beaumont Hospital but has also gained a wealth of experience abroad, working in the Alfred Hospital in Melbourne and as a volunteer aiming to improve nutrition education in both Guatemala and Vanuatu. She began working in Critical Care during the COVID-19 pandemic and has been passionate about providing optimal nutritional care in the ICU setting and beyond ever since. She has been involved in introducing indirect calorimetry into the intensive care unit in Beaumont Hospital and several international studies focused on nutrition in the ICU setting.
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Ms Aine Kelly, Clinical specialist Dietitian, Tallaght University Hospital
Aine Kelly is a Clinical Specialist Dietitian at Tallaght University Hospital. She graduated with first-class honours from Trinity College Dublin in 2009 and has over 15 years of clinical experience across five major teaching hospitals, including TUH, SJH, SVUH, Manchester Royal Infirmary, and Bradford Trust Teaching Hospital. Aine specializes in critical care nutrition, a field she has focused on for the past eleven years. In 2021, she earned an MSc in Exercise and Sports Nutrition, graduating top of her class. This enhanced her knowledge of nutrition’s role in stress, injury, and recovery. In 2022, Aine was seconded as the National HSCP Lead for Critical Care, representing 10 health and social care disciplines. Her work focused on workforce planning to support the national critical care expansion plan.
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Measuring Effectiveness in ICU Dietetics
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